01 - Set the oven temperature to 375°F.
02 - Boil salted water in a large pot and cook elbow macaroni according to package directions until al dente. Drain and set aside.
03 - In a large skillet over medium heat, cook diced bacon until crispy. Remove with a slotted spoon and set aside.
04 - Using the same skillet, cook ground beef over medium heat until browned and cooked through, breaking up meat with a spoon. Drain excess fat.
05 - Melt butter in a large saucepan over medium heat. Whisk in flour and cook for 1 minute to form a roux.
06 - Gradually whisk in milk, stirring constantly until smooth. Continue cooking until sauce thickens, about 5 minutes.
07 - Remove sauce from heat. Stir in cheddar, mozzarella, Dijon mustard, garlic powder, onion powder, black pepper, and salt until fully melted and smooth.
08 - In a large mixing bowl, combine cooked macaroni, crispy bacon, browned beef, and cheese sauce. Mix until evenly coated.
09 - Grease a 9x13 inch baking dish and transfer the mixture evenly into it.
10 - Mix panko breadcrumbs with melted butter and sprinkle evenly over the macaroni mixture.
11 - Bake in the preheated oven for 15 to 20 minutes until the topping is golden and bubbling.
12 - Sprinkle chopped fresh parsley on top before serving.